After completing his MSc in the Woodin lab, Petri joined Steven Prescott’s lab at SickKids in Toronto to learn multi-photon calcium imaging and computational neuroscience techniques. He is working on investigating how spinal interneuron GABAergic synapses onto peripheral nervous system sensory neurons can change from being inhibitory to excitatory, contributing to causing and maintaining chronic neuropathic pain.
Takkala, P, and Prescott, SA. (2018). Using dynamic clamp to quantify pathological changes in the excitability of primary somatosensory neurons. The Journal of Physiology. 596(11):2209-2227. doi: 10.1113/JP275580.
Takkala, P, Zhu, Y, and Prescott, SA. (2016). Combined changes in chloride regulation and neuronal excitability enable primary afferent depolarization to elicit spiking without compromising its inhibitory effects. PLoS Computational Biology. doi: 10.1371/journal.pcbi.1005215
Takkala, P, and Woodin, MA. (2013). Muscarinic acetylcholine receptor activation prevents disinhibition-mediated LTP in the hippocampus. Frontiers in Cellular Neuroscience. 7:16. doi: 10.3389/fncel.2013.00016.